AGENERASE (amprenavir) is an inhibitor of the human immunodeficiency virus
(HIV) protease. The chemical name of amprenavir is (3S)-tetrahydro-3-furyl
Amprenavir is a single stereoisomer with the (3S)(1S,2R)
configuration. It has a molecular formula of C25H35N3O6S
and a molecular weight of 505.64. It has the following structural formula:
Amprenavir is a white to cream-colored solid with a solubility of approximately
0.04 mg/mL in water at 25°C.
AGENERASE Capsules (amprenavir capsules) are available for oral administration. Each 50- mg
capsule contains the inactive ingredients d-alpha tocopheryl polyethylene glycol
1000 succinate (TPGS), polyethylene glycol 400 (PEG 400) 246.7 mg, and propylene
glycol 19 mg. The capsule shell contains the inactive ingredients d-sorbitol
and sorbitans solution, gelatin, glycerin, and titanium dioxide. The soft gelatin
capsules are printed with edible red ink. Each 50- mg AGENERASE Capsule contains
36.3 IU vitamin E in the form of TPGS. The total amount of vitamin E in the
recommended daily adult dose of AGENERASE is 1,744 IU.
Last reviewed on RxList: 7/16/2008
This monograph has been modified to include the generic and brand name in many instances.