AUBAGIO (teriflunomide) is an oral de novo pyrimidine synthesis
inhibitor of the DHO-DH enzyme, with the chemical name (Z)-2-Cyano-3-hydroxy-but-2-enoic
acid-(4-trifluoromethylphenyl)-amide. Its molecular weight is 270.21, and the
empirical formula is C12H9F3N2O2
with the following chemical structure:
Teriflunomide is a white to almost white powder that is sparingly
soluble in acetone, slightly soluble in polyethylene glycol and ethanol, very
slightly soluble in isopropanol and practically insoluble in water.
Teriflunomide is formulated as film-coated tablets for oral
administration. AUBAGIO tablets contain 7 mg or 14 mg of teriflunomide and the
following inactive ingredients: lactose monohydrate, corn starch,
hydroxypropylcellulose, microcrystalline cellulose, sodium starch glycolate,
and magnesium stearate. The film coating for the 14 mg tablet is made of hypromellose,
titanium dioxide, talc, polyethylene glycol and indigo carmine aluminum lake.
In addition to these, the 7 mg tablet film coating includes iron oxide yellow.
Last reviewed on RxList: 9/21/2012
This monograph has been modified to include the generic and brand name in many instances.