Autologous cultured chondrocytes, the Carticel (autologous cultured chondrocytes for implantation) product, are derived from in
vitro expansion of chondrocytes harvested from the patient's normal, femoral
articular cartilage. Biopsies from a lesser-weight bearing area are the source
of chondrocytes, which are isolated, expanded through cell culture, and implanted
into articular cartilage defects beneath an autologous periosteal flap. Prior
to final packaging, cell viability is assessed to be at least 80%.
Each single use container of autologous cultured chondrocytes has approximately
12 million cells aseptically processed and suspended in 0.4 mL of sterile, buffered
Dulbecco's Modified Eagles Medium (DMEM). Both the biopsy transport media and
the cell culture media contain gentamicin. Residual quantities of gentamicin
up to 5 μg/mL may be present in the Carticel (autologous cultured chondrocytes for implantation) product.
Last reviewed on RxList: 12/22/2010
This monograph has been modified to include the generic and brand name in many instances.