BELVIQ (lorcaserin hydrochloride) is a serotonin 2C receptor
agonist for oral administration used for chronic weight management. Its
chemical name is (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
hydrochloride hemihydrate. The empirical formula is C11H15Cl2N•0.5H2O,
and the molecular weight of the hemihydrate form is 241.16 g/mol.
The structural formula is:
Lorcaserin hydrochloride hemihydrate is a white to off-white
powder with solubility in water greater than 400 mg/mL. Each BELVIQ tablet
contains 10.4 mg of crystalline lorcaserin hydrochloride hemihydrate,
equivalent to 10.0 mg anhydrous lorcaserin hydrochloride, and the following
inactive ingredients: silicified microcrystalline cellulose; hydroxypropyl
cellulose NF; croscarmellose sodium NF; colloidal silicon dioxide NF, polyvinyl
alcohol USP, polyethylene glycol NF, titanium dioxide USP, talc USP, FD&C
Blue #2 aluminum lake, and magnesium stearate NF.
Last reviewed on RxList: 7/5/2012
This monograph has been modified to include the generic and brand name in many instances.