COMETRIQ is the (S)-malate salt of cabozantinib.
Cabozantinib (S)-malate is described chemically as N-(4-(6,7-dimethoxyquinolin-4-yloxy)phenyl)-N'-(4-fluorophenyl)cyclopropane-
1,1-dicarboxamide, (2S)-hydroxybutanedioate. The molecular formula is C28H24FN3O5•C4H6O5
and the molecular weight is 635.6 Daltons as malate salt. The chemical
structure of cabozantinib (S)-malate salt is:
Cabozantinib (S)-malate salt is a white to off-white
solid that is practically insoluble in aqueous media.
COMETRIQ (cabozantinib) capsules are supplied as printed
hard gelatin capsules containing cabozantinib (S)-malate equivalent to 20 mg or
80 mg cabozantinib and the following inactive ingredients: silicified
microcrystalline cellulose, croscarmellose sodium, sodium starch glycolate, fumed
silica, and stearic acid.
The grey gelatin capsule shells contain black iron oxide
and titanium dioxide and the Swedish orange gelatin capsule shells contain red
iron oxide, and titanium dioxide. The printing ink contains shellac glaze,
black iron oxide, N-butyl alcohol, isopropyl alcohol, propylene glycol, and
Last reviewed on RxList: 12/6/2012
This monograph has been modified to include the generic and brand name in many instances.