Human secretin is a gastrointestinal peptide hormone produced by cells in the duodenum in response to acidification. ChiRhoStim® (human secretin as the acetate) is a purified synthetic peptide with an amino acid sequence identical to the naturally occurring hormone. Synthetic human secretin is chemically defined as follows:
Molecular Weight 3039.44
Empirical Formula: C130H220N44O39
CAS # 108153-74-8
ChiRhoStim® (human secretin) is available in two strengths:
- As a 10 ml vial which contains 16 mcg of purified synthetic human secretin,
1.5 mg of L-cysteine hydrochloride, 20 mg of mannitol, and 9 mg of sodium
chloride. When reconstituted in 8 mL of Sodium Chloride Injection USP, each
mL of solution contains 2 mcg synthetic human secretin for intravenous use.
The pH of the reconstituted solution has a range of 3 to 6.5.
- As a 10 ml vial which contains 40 mcg of purified synthetic human secretin,
3.75 mg of L-cysteine hydrochloride, 50 mg of mannitol, and 22.5 mg of sodium
chloride per vial. When reconstituted in 10 mL of Sodium Chloride Injection
USP, each mL of solution contains 4 mcg synthetic human secretin for intravenous
use. The pH of the reconstituted solution has a range of 3 to 6.5.
Last reviewed on RxList: 7/17/2007
This monograph has been modified to include the generic and brand name in many instances.