The active component of ZETONNA Nasal Aerosol is
ciclesonide, a non-halogenated glucocorticoid having the chemical name pregna
Ciclesonide is delivered as the R-epimer. The empirical formula is C32H44O7
and its molecular weight is 540.7. Its structural formula is as follows:
Ciclesonide is a white to yellow-white powder. It is soluble
in dehydrated alcohol, acetone, dichloromethane, and chloroform. ZETONNA Nasal
Aerosol is comprised of a pressurized, metered-dose aerosol canister and
actuator, which is fitted with a dose indicator. ZETONNA Nasal Aerosol is
intended for intranasal use only. Each canister contains a solution of
ciclesonide in propellant HFA-134a (1,1,1,2 tetrafluoroethane) and ethanol.
After priming, ZETONNA Nasal Aerosol 37 mcg delivers 50 mcg of ciclesonide from
the valve and 37 mcg of ciclesonide from the actuator. This product delivers 50
microliters (59.3 milligrams) of solution as fine particle mist from the valve
with each actuation.
Last reviewed on RxList: 2/6/2012
This monograph has been modified to include the generic and brand name in many instances.