Cleviprex is a sterile, milky-white emulsion containing 0.5 mg/mL of clevidipine
suitable for intravenous administration. Clevidipine is a dihydropyridine calcium
channel blocker. Chemically, the active substance,clevidipine,is butyroxymethyl
It is a racemic mixture with a molecular weight of 456.3 g/mol. Each enantiomer
has equipotent antihypertensive activity. The structure and formula are:
Clevidipineis practically insoluble in water and is formulated in an oil-in-water
emulsion. In addition to the active ingredient, clevidipine, Cleviprex contains
soybean oil(200 mg/mL), glycerin (22.5 mg/mL), purified egg yolk phospholipids
(12 mg/mL),oleic acid (0.3 mg/mL), disodium edetate (0.05 mg/mL), and sodium
hydroxide to adjust pH. Cleviprex has a pH of 6.0 - 8.0 and is a ready-to-use
What are the possible side effects of clevidipine (Cleviprex)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
- feeling like you might pass out;
- slow heart rate;
- urinating less than usual or not at all;
- drowsiness, confusion, mood changes, increased thirst, loss of appetite, vomiting;
- feeling short of breath, even with mild exertion;
- swelling, rapid weight gain; or
- chest pain or heavy feeling, pain...
Read All Potential Side Effects and See Pictures of Cleviprex »
Last reviewed on RxList: 1/4/2012
This monograph has been modified to include the generic and brand name in many instances.