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CREON® 20
MINIMICROSPHERES®
(pancrelipase) Delayed-release Capsules, USP

DRUG DESCRIPTION

CREON® 20 Capsules are orally administered and contain pancrelipase (lipase 20,000 USP Units, protease 75,000 USP Units and amylase 66,400 USP Units per capsule) which is of porcine pancreatic origin. Each CREON 20 (pancrelipase delayed-released capsules) Capsule is filled with 497 mg of delayed-release MINIMICROSPHERES®.

Inactive ingredients include dibutyl phthalate, dimethicone, hydroxypropylmethylcellulose phthalate, light mineral oil and polyethylene glycol. The capsule shells contain gelatin, red iron oxide, titanium dioxide and yellow iron oxide. The capsule imprinting ink contains dimethicone, 2-ethoxyethanol, shellac, soya lecithin, and titanium dioxide.

What are the possible side effects of pancrelipase?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have severe or unusual stomach pain. This could be a symptom of a rare but serious bowel disorder.

Less serious side effects may include:

  • nausea or vomiting;
  • mild stomach pain or upset;
  • diarrhea or constipation;
  • bloating or gas.
  • greasy stools;
  • rectal irritation;
  • headache, dizziness;
  • cough; or
  • weight...

Read All Potential Side Effects and See Pictures of Creon 20 »

What are the precautions when taking pancrelipase delayed-released capsules (Creon 20)?

Before taking pancrelipase, tell your doctor or pharmacist if you are allergic to it; or to pork protein; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: sudden/severe swelling of the pancreas (acute pancreatitis), sudden worsening of long-term disease of the pancreas.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: gout, kidney disease, high uric acid level in the blood (hyperuricemia), intestinal problems (such as blockage).

This drug may...

Read All Potential Precautions of Creon 20 »

Last reviewed on RxList: 9/29/2008
This monograph has been modified to include the generic and brand name in many instances.