Cyanocobalamin is a synthetic form of vitamin B12 with activity
equivalent to the endogenous form of vitamin B12. The chemical name
is α-(5,6-dimethylbenzimidazolyl) cyanocobamide. The cobalt content is
4.35%. The molecular formula is C63H88CoN14O14P,
which corresponds to a molecular weight of 1355.4 and the following structural
Cyanocobalamin occurs as dark red crystals, orthorhombic needles, or crystalline
red powder and is very hygroscopic in the anhydrous form, and sparingly to moderately
soluble in water (1:80). The pharmacologic activity of cyanocobalamin is destroyed
by heavy metals (iron) and strong oxidizing or reducing agents (Vitamin C),
but not by autoclaving for short periods of time (15-20 minutes) at 121°
C. The vitamin B12 coenzymes are very unstable in light.
Each bottle of CaloMist Nasal Spray contains cyanocobalamin, sodium
chloride, sodium phosphate monobasic, benzyl alcohol, sodium hydroxide, and
benzalkonium chloride in purified water with an attached spray pump unit.
Last reviewed on RxList: 8/16/2007
This monograph has been modified to include the generic and brand name in many instances.