Hydroxocobalamin, the active ingredient in Cyanokit, is cobinamide dihydroxide
dihydrogen phosphate (ester), mono (inner salt), 3'-ester with 5,6-dimethyl-1-α-D-ribofuranosyl-1H-benzimidazole.
The drug substance is the hydroxylated active form of vitamin B12 and is a large
molecule in which a trivalent cobalt ion is coordinated in four positions by
a tetrapyrol (or corrin) ring. It is a hygroscopic, odorless, dark red, crystalline
powder that is freely soluble in water and ethanol, and practically insoluble
in acetone and diethyl ether. Hydroxocobalamin has a molecular weight of 1346.36
atomic mass units, an empirical formula of C62H89CoN13O15P
and the following structural formula:
Cyanokit (hydroxocobalamin for injection) 5 g for intravenous infusion is a
cyanide antidote package which contains one colorless 250 mL glass vial, containing
5 g dark red lyophilized hydroxocobalamin, pH adjusted with hydrochloric acid,
one transfer spike, one intravenous administration set, one quick use reference
guide and one package insert.
The 5 g vial of hydroxocobalamin for injection is to be reconstituted with
200 mL of 0.9% NaCl, to give a dark red injectable solution (25 mg/mL). If 0.9%
NaCl is not readily available, 200 mL of either Lactated Ringers injection or
5% Dextrose injection (D5W) may be used as the diluent. Diluent is not included
in the Cyanokit. The pH of the reconstituted product ranges from 3.5 to 6.0.
What are the possible side effects of hydroxocobalamin (Cyanokit, Hydroxocobalamin)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; chest tightness, difficulty breathing; swelling of your face, lips, tongue, or throat.
You may develop an acne-like skin rash within 1 to 4 weeks after you are treated with hydroxocobalamin. This rash should go away without treatment. Call your doctor if you have a rash that lasts longer than 4 weeks.
Call your doctor at once if you have a serious side effect such as:
- bright red blood in your stools;
- chest pain, fast or uneven heart...
Read All Potential Side Effects and See Pictures of Cyanokit »
Last reviewed on RxList: 5/26/2011
This monograph has been modified to include the generic and brand name in many instances.