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DURAMORPH
(morphine sulfate) Injection, USP

Not For Use in Continuous Microinfusion Devices

DRUG DESCRIPTION

Morphine is the most important alkaloid of opium and is a phenanthrene derivative. It is available as the sulfate salt, having the following structural formula:

DURAMORPH
  (morphine sulfate) Structural Formula Illustration

7,8-Didehydro-4,5-epoxy-17-methyl-(5α,6α)-morphinan-3,6-diol sulfate (2:1) (salt), pentahydrate
(C17H19NO3)2 • H2SO4 • 5H2O      Molecular Weight is 758.83

Preservative-free DURAMORPH (morphine sulfate injection, USP) is a sterile, nonpyrogenic, isobaric solution of morphine sulfate, free of antioxidants, preservatives or other potentially neurotoxic additives and is intended for intravenous, epidural or intrathecal administration as a narcotic analgesic. Each milliliter contains morphine sulfate 0.5 mg or 1 mg and sodium chloride 9 mg in Water for Injection. pH range is 2.5-6.5. Each 10 mL DOSETTE ampul of DURAMORPH (morphine injection) is intended for SINGLE USE ONLY. Discard any unused portion. DO NOT HEAT-STERILIZE.

What are the precautions when taking morphine injection (Duramorph)?

Before using morphine injection, tell your doctor or pharmacist if you are allergic to it; or to other narcotic pain medications (such as codeine); or if you have any other allergies. This product may contain inactive ingredients (such as sulfites found in some brands), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: certain bowel diseases (paralytic ileus, infectious diarrhea).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, lung diseases (such as asthma, chronic obstructive pulmonary...

Read All Potential Precautions of Duramorph »

Last reviewed on RxList: 10/29/2010
This monograph has been modified to include the generic and brand name in many instances.