Edarbyclor is a combination of azilsartan medoxomil (ARB; as
its potassium salt) and chlorthalidone (thiazide-like diuretic).
Azilsartan medoxomil, a prodrug, is hydrolyzed to azilsartan
in the gastrointestinal tract during absorption. Azilsartan is a selective AT1 subtype
angiotensin II receptor antagonist. Chlorthalidone is a monosulfamyl
thiazide-like diuretic that differs chemically from thiazide diuretics by the
lack of a benzothiadiazine structure.
The potassium salt of azilsartan medoxomil, azilsartan
kamedoxomil, is chemically described as (5Methyl-2-oxo-1,3-dioxol-4-yl)methyl
monopotassium salt. Its empirical formula is C30H23KN4O8.
Chlorthalidone is chemically described as
2-chloro-5(1-hydroxy-3-oxo-1- isoindolinyl) benzenesulfonamide. Its empirical
formula is C14H11ClN2O4S.
The structural formula for azilsartan medoxomil is
This structural formula for chlorthalidone is
Azilsartan kamedoxomil is a white
to nearly white powder with a molecular weight of 606.62. It is practically
insoluble in water and freely soluble in methanol.
Chlorthalidone is a white to
yellowish white powder with a molecular weight of 338.76. Chlorthalidone is
practically insoluble in water, in ether, and in chloroform; soluble in methanol;
slightly soluble in ethanol.
Edarbyclor is available for oral
use as tablets. The tablets have a characteristic odor. Each Edarbyclor tablet
contains 42.68 mg of azilsartan kamedoxomil, which is equivalent to containing
azilsartan medoxomil 40 mg plus 12.5 or 25 mg of chlorthalidone. Each tablet of
Edarbyclor also contains the following inactive ingredients: mannitol,
microcrystalline cellulose, fumaric acid, sodium hydroxide, hydroxypropyl
cellulose, crospovidone, magnesium stearate, hypromellose 2910, talc, titanium
dioxide, ferric oxide red, polyethylene glycol 8000, and printing ink gray F1.
Last reviewed on RxList: 10/16/2012
This monograph has been modified to include the generic and brand name in many instances.