Endrate (Edetate Disodium Injection, USP) is a sterile,
nonpyrogenic, concentrated solution of edetate disodium in water for injection which
as a result of a pH adjustment with sodium hydroxide contains varying amounts
of disodium and trisodium salts. After dilution, it is administered by
Each mL contains edetate disodium, anhydrous 150 mg. May
contain sodium hydroxide for pH adjustment. pH is 7.0 (6.5 to 7.5). Edetate
disodium is classified as a clinical chelating agent for emergency lowering of
serum calcium in hypercalcemia. The solution contains no bacteriostat,
antimicrobial agent or buffer (except for pH adjustment) and is intended only
for use (after dilution) as a single-dose infusion. When smaller doses are
required, the unused portion should be discarded.
Edetate Disodium, USP is chemically designated disodium
(ethylenedinitrilo) tetraacetate dihydrate, a white crystalline powder soluble
in water. It is also described as the disodium salt of ethylenediamine
tetraacetic acid (EDTA) and has the following structural formula:
What are the possible side effects of edetate disodium (Disotate, Endrate)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Tell your caregivers at once if you have any of these serious side effects:
- feeling like you might pass out; or
- severe blistering, peeling, or red skin rash.
Less serious side effects include:
- nausea, vomiting, diarrhea;
- numbness or tingling (especially around your mouth);
- headache; or
- pain, redness, or swelling where the needle is...
Read All Potential Side Effects and See Pictures of Endrate »
Last reviewed on RxList: 5/27/2009
This monograph has been modified to include the generic and brand name in many instances.