HALAVEN (eribulin mesylate) Injection is a non-taxane
microtubule dynamics inhibitor. Eribulin mesylate is a synthetic analogue of
halichondrin B, a product isolated from the marine sponge
Halichondria okadai. The chemical name for eribulin mesylate is 11,15:18,21:24,28Triepoxy-7,9-ethano-12,15-methano-9H,15H-furo[3,2-i]furo[2',3':5,6]pyrano[4,3b][1,4]dioxacyclopentacosin-5(4H)-one,
methanesulfonate (salt). It has a molecular weight of 826.0 (729.9 for free
base). The empirical formula is C40H59NO11•CH4O3S.
Eribulin mesylate has the following structural formula:
HALAVEN is a clear, colorless,
sterile solution for intravenous administration. Each vial contains 1 mg of
eribulin mesylate as a 0.5 mg/mL solution in ethanol: water (5:95).
What are the possible side effects of eribulin (Halaven)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
- fever, chills, body aches, flu symptoms, sores in your mouth and throat;
- pain or burning when you urinate;
- pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating;
- severe numbness or tingling in your hands and feet;
- low potassium (confusion, uneven heart rate, extreme thirst,...
Read All Potential Side Effects and See Pictures of Halaven »
Last reviewed on RxList: 3/2/2012
This monograph has been modified to include the generic and brand name in many instances.