Vismodegib is an inhibitor of the hedgehog (Hh) signaling
pathway, which is described chemically as 2-Chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide.
The molecular formula is C19H14Cl2N2O3S.
The molecular weight is 421.30 g/mol and the structural formula is:
Vismodegib is a crystalline free base with a pKa
(pyridinium cation) of 3.8, appearing as a white to tan powder. The solubility
of vismodegib is pH dependent with 0.1 μg/mL at pH 7 and 0.99 mg/mL at pH
1. The partition coefficient (log P) is 2.7.
Each ERIVEDGE (vismodegib) capsule for oral
administration contains 150 mg vismodegib and the following inactive
ingredients: microcrystalline cellulose, lactose monohydrate, sodium lauryl
sulfate, povidone, sodium starch glycolate, talc, and magnesium stearate
(non-bovine). The capsule shell contains gelatin, titanium dioxide, red iron
oxide, and black iron oxide. The black printing ink contains shellac and black
Last reviewed on RxList: 2/2/2012
This monograph has been modified to include the generic and brand name in many instances.