VYTORIN contains ezetimibe, a
selective inhibitor of intestinal cholesterol and related phytosterol
absorption, and simvastatin, an HMG-CoA reductase inhibitor.
The chemical name of ezetimibe is
The empirical formula is C24H21F2NO3
and its molecular weight is 409.4.
Ezetimibe is a white, crystalline
powder that is freely to very soluble in ethanol, methanol, and acetone and
practically insoluble in water. Its structural formula is:
Simvastatin, an inactive lactone,
is hydrolyzed to the corresponding β-hydroxyacid form, which is an
inhibitor of HMG-CoA reductase. Simvastatin is butanoic acid,
ester, [1S-[1α,3α,7β,8β(2S*,4S*),-8aβ]]. The empirical
formula of simvastatin is C25H38O5 and its molecular weight is 418.57.
Simvastatin is a white to
off-white, nonhygroscopic, crystalline powder that is practically insoluble in
water and freely soluble in chloroform, methanol and ethanol. Its structural
VYTORIN is available for oral use
as tablets containing 10 mg of ezetimibe, and 10 mg of simvastatin (VYTORIN
10/10), 20 mg of simvastatin (VYTORIN 10/20), 40 mg of simvastatin (VYTORIN
10/40), or 80 mg of simvastatin (VYTORIN 10/80). Each tablet contains the
following inactive ingredients: butylated hydroxyanisole NF, citric acid
monohydrate USP, croscarmellose sodium NF, hypromellose USP, lactose
monohydrate NF, magnesium stearate NF, microcrystalline cellulose NF, and
propyl gallate NF.
What are the possible side effects of ezetimibe and simvastatin (Vytorin)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop taking ezetimibe and simvastatin and call your doctor at once if you have any of these serious side effects:
- unexplained muscle pain, tenderness, or weakness;
- fever, unusual tiredness, and dark colored urine;
- swelling, weight gain, urinating less than usual or not at all;
- chest pain, dry cough, wheezing, feeling short of breath;
- severe pain in your upper...
Read All Potential Side Effects and See Pictures of Vytorin »
What are the precautions when taking ezetimibe and simvastatin (Vytorin)?
Before taking this product, tell your doctor or pharmacist if you are allergic to ezetimibe or simvastatin; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, alcohol use.
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
Limit alcoholic beverages. Daily use of alcohol may increase your risk for liver problems, especially when combined with this product. Ask your doctor or pharmacist for more...
Read All Potential Precautions of Vytorin »
Last reviewed on RxList: 2/24/2012
This monograph has been modified to include the generic and brand name in many instances.