FYCOMPA tablets contain perampanel, a non-competitive AMPA receptor
antagonist. Perampanel is described chemically as
2-(2-oxo-1-phenyl-5-pyridin-2-yl-1,2-dihydropyridin-3-yl) benzonitrile hydrate
The molecular formula is C23H15N3O •
3/4H2O and the molecular weight is 362.90 (3/4 hydrate). The chemical
structure of perampanel is:
Perampanel is a white to yellowish white
powder. It is freely soluble in N-methylpyrrolidone, sparingly soluble in
acetonitrile and acetone, slightly soluble in methanol, ethanol and ethyl
acetate, very slightly soluble in 1-octanol and diethyl ether and practically
insoluble in heptane and water.
FYCOMPA (perampanel) tablets are round,
bi-convex, film coated tablets containing 2 mg, 4 mg, 6 mg, 8 mg, 10 mg or 12
mg of perampanel. Tablets contain the following inactive ingredients: lactose
monohydrate, low substituted hydroxypropyl cellulose, povidone,
microcrystalline cellulose, magnesium stearate, hypromellose, polyethylene
glycol, talc and titanium dioxide. Tablets of different strengths also may
contain yellow ferric oxide (10 mg and 2 mg), red ferric oxide (2 mg, 4 mg, 6
mg, 8 mg), black ferric oxide (8 mg) and FD&C blue # 2 indigo carmine
aluminum lake (10 mg and 12 mg).
Last reviewed on RxList: 11/1/2012
This monograph has been modified to include the generic and brand name in many instances.