EOVIST (gadoxetate disodium) is a paramagnetic contrast agent for MRI. EOVIST
is provided as a sterile, clear, colorless to pale yellow aqueous solution for
EOVIST contains the active pharmaceutical ingredient gadoxetate disodium (Gd-EOB-DTPA),
which is designated chemically as (4S)-4-(4-Ethoxybenzyl)-3,6,9-tris(carboxylatomethyl)-3,6,9triazaundecanedioic
acid, gadolinium complex, disodium salt with a molecular weight of 725.72 and
an empirical formula of GdC23H28N3O11Na2.
The structural formula of gadoxetate disodium in aqueous solution is:
Each mL of EOVIST contains 181.43 mg of gadoxetate disodium (equivalent to
0.25 mol/L gadoxetate disodium) and the excipients caloxetate trisodium, trometamol,
hydrochloric acid and/or sodium hydroxide (for pH adjustment), and water for
injection. EOVIST contains no antimicrobial preservative.
EOVIST has a pH of 6.8 to 8. Pertinent physiochemical data are provided below:
TABLE 2 : Physicochemical Properties
|Osmolality at 37°C (Osm/kg H2O)
|Viscosity at 37°C (cP)
|Density at 37°C (g/mL)
What are the possible side effects of gadoxetate (Eovist)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Some of the side effects of gadoxetate can occur up to several days after you have received the medication.
Call your doctor at once if you have a serious side effect such as:
- urinating less than usual or not at all;
- drowsiness, confusion, mood changes, increased thirst, loss of appetite;
- swelling, weight gain, feeling short of breath; or
- swelling, irritation, or skin changes where...
Read All Potential Side Effects and See Pictures of Eovist »
Last reviewed on RxList: 12/7/2011
This monograph has been modified to include the generic and brand name in many instances.