HEMABATE (carboprost tromethamine) Sterile Solution, an oxytocic, contains the tromethamine salt of the
(15S)-15 methyl analogue of naturally occurring prostaglandin F2α in a
solution suitable for intramuscular injection.
Carboprost tromethamine is the established name for the active ingredient in
HEMABATE (carboprost tromethamine) . Four other chemical names are:
- (15S)-15-methyl prostaglandin F2α tromethamine salt
acid compound with 2-amino-2-(hydroxymethyl)-1,3-propanediol
- (15S)-9α,11α,15-trihydroxy-15-methylprosta-cis-5, trans-13-dienoic
acid tromethamine salt
- (15S)-15-methyl PGF2α-THAM
The structural formula is represented below:
The molecular formula is C25H47O8N. The molecular
weight of carboprost tromethamine is 489.64. It is a white to slightly off-white
crystalline powder. It generally melts between 95° and 105° C, depending
on the rate of heating.
Carboprost tromethamine dissolves readily in water at room temperature at a
concentration greater than 75 mg/mL.
Each mL of HEMABATE Sterile Solution contains carboprost tromethamine equivalent
to 250 mcg of carboprost, 83 mcg tromethamine, 9 mg sodium chloride, and 9.45
mg benzyl alcohol added as preservative. When necessary, pH is adjusted with
sodium hydroxide and/or hydrochloric acid. The solution is sterile.
What are the possible side effects of carboprost (Hemabate)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:
- severe pelvic pain, cramping, or vaginal bleeding;
- high fever;
- feeling light-headed or short of breath;
- severe nausea, vomiting, or diarrhea; or
- increased blood pressure (severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure).
Less serious side effects...
Read All Potential Side Effects and See Pictures of Hemabate »
Last reviewed on RxList: 5/7/2008
This monograph has been modified to include the generic and brand name in many instances.