Topotecan hydrochloride is a semi-synthetic derivative of camptothecin and
is an anti-tumor drug with topoisomerase I-inhibitory activity.
The chemical name for topotecan hydrochloride is (S)-10-[(dimethylamino)methyl]-4ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]
indolizino [1,2-b]quinoline-3,14-(4H,12H)-dione monohydrochloride. It has the
molecular formula C23H23N3O5•HCl
and a molecular weight of 457.9. It is soluble in water and melts with decomposition
at 213° to 218°C
Topotecan hydrochloride has the following structural formula:
HYCAMTIN capsules contain topotecan hydrochloride, the content of which is
expressed as topotecan free base. The major excipients are hydrogenated vegetable
oil, glyceryl monostearate, gelatin, and titanium dioxide. The capsules are
imprinted with edible black ink. The 1 mg capsules also contain red iron oxide.
What are the possible side effects of topotecan (Hycamtin)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
- wheezing, feeling short of breath, chest pain, dry cough;
- fever, chills, flu symptoms, mouth and throat ulcers, rapid and shallow breathing, fainting;
- pale skin, feeling light-headed, rapid heart rate, trouble concentrating;
- easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots...
Read All Potential Side Effects and See Pictures of Hycamtin Capsules »
Last reviewed on RxList: 7/26/2010
This monograph has been modified to include the generic and brand name in many instances.