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NeoProfen
(ibuprofen lysine) Injection for Intravenous Use

DRUG DESCRIPTION

NeoProfen (ibuprofen lysine injection) ® is a clear sterile preservative-free solution of the l-lysine salt of (±)-ibuprofen which is the active ingredient. (±)-Ibuprofen is a nonsteroidal anti-inflammatory agent (NSAID). L-lysine is used to create a water-soluble drug product salt suitable for intravenous administration. Each mL of NeoProfen contains 17.1 mg of ibuprofen lysine (equivalent to 10 mg of (±)-ibuprofen) in Water for Injection, USP. The pH is adjusted to 7.0 with sodium hydroxide or hydrochloric acid.

The structural formula is:

NeoProfen
  (ibuprofen lysine) Structural Formula Illustration

NeoProfen (ibuprofen lysine injection) is designated chemically as a-methyl-4-(2-methyl propyl) benzeneacetic acid lysine salt. Its molecular weight is 352.48. Its empirical formula is C19H32N2O4. It occurs as a white crystalline solid which is soluble in water and slightly soluble in ethanol.

Last reviewed on RxList: 1/20/2010
This monograph has been modified to include the generic and brand name in many instances.