SKLICE (ivermectin) Lotion, for topical administration, is an off-white/tan lotion containing 0.5% ivermectin.
Ivermectin, the active ingredient, is a pediculicide, derived from the fermentation
of a soil dwelling actinomycete, Streptomyces avermitilis.
Ivermectin is a mixture containing at least 90% 5-O-demethyl-22,23-dihydroavermectin
A1a and less than 10% 5-O-demethyl-25-de(l -methylpropyl)-22,23-dihydro25-(l-methylethyl)
avermectin A1a, generally referred to as 22,23-dihydroavermectin
B1a and B1b, or H2B1a and H2B1b,
respectively. The respective empirical formulas are C48H74O14
and C47H72O14, with molecular weights of 875.10
and 861.07, respectively. The structural formulas are:
Component H2B1a: R = CH2CH3 Component
H2B1b: R = CH3
SKLICE Lotion contains the following inactive ingredients: water, olive oil, oleyl alcohol, Crodalan AWS, lanolin alcohol, cyclomethicone, shea butter, sodium citrate, sorbitan tristearate, methylparaben, propylparaben, and citric acid.
Last reviewed on RxList: 2/22/2012
This monograph has been modified to include the generic and brand name in many instances.