JUXTAPID capsules contain lomitapide mesylate, a
synthetic lipidlowering agent for oral administration.
The chemical name of lomitapide mesylate is
piperidinyl]butyl]-9H-fluorene-9-carboxamide, methanesulfonate salt. Its
structural formula is:
The empirical formula for lomitapide mesylate is C39H37F6N3O2
•CH4O3S and its molecular weight is 789.8.
Lomitapide mesylate is a white to off-white powder that
is slightly soluble in aqueous solutions of pH 2 to 5. Lomitapide mesylate is
freely soluble in acetone, ethanol, and methanol; soluble in 2-butanol,
methylene chloride, and acetonitrile; sparingly soluble in 1-octanol and
2-propanol; slightly soluble in ethyl acetate; and insoluble in heptane.
Each JUXTAPID capsule contains lomitapide mesylate equivalent
to 5, 10, or 20 mg lomitapide free base and the following inactive ingredients:
pregelatinized starch, sodium starch glycolate, microcrystalline cellulose,
lactose monohydrate, silicon dioxide and magnesium stearate. The capsule shells
contain gelatin and titanium dioxide. In addition, the orange capsule shells
contain red iron oxide. The imprinting ink contains shellac, black iron oxide,
and propylene glycol.
Last reviewed on RxList: 1/7/2013
This monograph has been modified to include the generic and brand name in many instances.