Lamprene, clofazimine, is an antileprosy agent available as soft gelatin capsules for oral administration. Each capsule contains 50 mg of micronized clofazimine suspended in an oil-wax base. Clofazimine is a substituted iminophenazine bright-red dye. Its chemical name is 3-(p-chloroanilino)-10-(p-chlorophenyl)-2,
10-dihydro-2-isopropyliminophenazine, and its structural formula is
Clofazimine is a reddish-brown powder. It is readily soluble in benzene; soluble in chloroform; poorly soluble in acetone and in ethyl acetate; sparingly soluble in methanol and in ethanol; and virtually insoluble in water. Its molecular weight is 473.4.
Inactive Ingredients. Beeswax, butylated hydroxytoluene, citric
acid, ethyl vanillin, gelatin, glycerin, iron oxide, lecithin, p-methoxy acetophenone,
parabens, plant oils, propylene glycol.
Last reviewed on RxList: 11/5/2008
This monograph has been modified to include the generic and brand name in many instances.