The active ingredient in PREVACID
Delayed-Release Capsules and PREVACID SoluTab Delayed-Release Orally
Disintegrating Tablets is lansoprazole, a substituted benzimidazole,
2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl] methyl] sulfinyl]
benzimidazole, a compound that inhibits gastric acid secretion. Its empirical
formula is C16H14F3N3O2S
with a molecular weight of 369.37. PREVACID has the following structure:
Lansoprazole is a white to
brownish-white odorless crystalline powder which melts with decomposition at
approximately 166°C. Lansoprazole is freely soluble in dimethylformamide;
soluble in methanol; sparingly soluble in ethanol; slightly soluble in ethyl
acetate, dichloromethane and acetonitrile; very slightly soluble in ether; and
practically insoluble in hexane and water.
Lansoprazole is stable when
exposed to light for up to two months. The rate of degradation of the compound
in aqueous solution increases with decreasing pH. The degradation half-life of
the drug substance in aqueous solution at 25°C is approximately 0.5 hour at pH
5.0 and approximately 18 hours at pH 7.0.
PREVACID is supplied in
delayed-release capsules and in delayed-release orally disintegrating tablets
for oral administration.
The delayed-release capsules are
available in two dosage strengths: 15 mg and 30 mg of lansoprazole per capsule.
Each delayed-release capsule contains enteric-coated granules consisting of 15
mg or 30 mg of lansoprazole (active ingredient) and the following inactive
ingredients: sugar sphere, sucrose, methacrylic acid copolymer, low substituted
hydroxypropyl cellulose, starch, magnesium carbonate, talc, polyethylene
glycol, titanium dioxide, polysorbate 80, hydroxypropyl cellulose, colloidal
silicon dioxide, D&C Red No. 28, FD&C Blue No. 1, FD&C Green No. 31,
and FD&C Red No. 40.
PREVACID SoluTab Delayed-Release
Orally Disintegrating Tablets are available in two dosage strengths: 15 mg and
30 mg of lansoprazole per tablet. Each delayed-release orally disintegrating
tablet contains enteric-coated microgranules consisting of 15 mg or 30 mg of
lansoprazole (active ingredient) and the following inactive ingredients:
mannitol, methacrylic acid, hydroxypropyl cellulose, lactose
monohydrate-microcrystalline cellulose sphere, triethyl citrate, crospovidone,
polyacrylate, magnesium carbonate, aspartame2, glyceryl
monostearate, hypromellose, magnesium stearate, citric acid, titanium dioxide,
talc, artificial strawberry flavor, polyethylene glycol, polysorbate 80 and
1 PREVACID 15-mg capsules only.
2 Phenylketonurics: Contains Phenylalanine 2.5 mg per 15 mg
Tablet and 5.1 mg per 30 mg Tablet.
What are the possible side effects of lansoprazole (Prevacid, Prevacid OTC, Prevacid SoluTab)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using lansoprazole and call your doctor at once if you have symptoms of low magnesium:
- dizziness, confusion;
- fast or uneven heart rate;
- jerky muscle movements;
- feeling jittery;
- muscle cramps, muscle weakness or limp feeling;
- cough or choking feeling; or
Less serious side effects may...
Read All Potential Side Effects and See Pictures of Prevacid »
What are the precautions when taking lansoprazole (Prevacid)?
Before taking lansoprazole, tell your doctor or pharmacist if you are allergic to it; or to similar drugs (such as omeprazole, pantoprazole); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease.
Some symptoms may actually be signs of a more serious condition. Tell your doctor immediately if you have: heartburn with lightheadedness/sweating/dizziness, chest pain or shoulder pain (especially with trouble breathing, sweating, lightheadedness, pain spreading to arms/jaw/neck/shoulders), unexplained weight loss.
In addition, before you...
Read All Potential Precautions of Prevacid »
Last reviewed on RxList: 5/18/2012
This monograph has been modified to include the generic and brand name in many instances.