LESCOL is a water-soluble
cholesterol lowering agent which acts through the inhibition of
3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase.
Fluvastatin sodium is [R*,S*-(E)]-(±)-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic
acid, monosodium salt. The empirical formula of fluvastatin sodium is C24H25FNO4•Na,
its molecular weight is 433.46 and its structural formula is:
This molecular entity is the first
entirely synthetic HMG-CoA reductase inhibitor, and is in part structurally
distinct from the fungal derivatives of this therapeutic class.
Fluvastatin sodium is a white to
pale yellow, hygroscopic powder soluble in water, ethanol and methanol. LESCOL
is supplied as capsules containing fluvastatin sodium, equivalent to 20 mg or
40 mg of fluvastatin, for oral administration. LESCOL XL is supplied as
extended-release tablets containing fluvastatin sodium, equivalent to 80 mg of
fluvastatin, for oral administration.
Active Ingredient: fluvastatin sodium
Inactive Ingredients in
carbonate, gelatin, magnesium stearate, microcrystalline cellulose,
pregelatinized starch (corn), red iron oxide, sodium bicarbonate, talc,
titanium dioxide, yellow iron oxide, and other ingredients.
Capsules may also include: benzyl alcohol, black
iron oxide, butylparaben, carboxymethylcellulose sodium, edetate calcium
disodium, methylparaben, propylparaben, silicon dioxide, sodium lauryl sulfate,
and sodium propionate.
Inactive Ingredients in
extended-release tablets: microcrystalline cellulose, hydroxypropyl cellulose,
hydroxypropyl methyl cellulose, potassium bicarbonate, povidone, magnesium
stearate, yellow iron oxide, titanium dioxide and polyethylene glycol 8000.
What are the possible side effects of fluvastatin (Lescol, Lescol XL)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop taking fluvastatin and call your doctor at once if you have any of these serious side effects:
- unexplained muscle pain, tenderness, or weakness;
- fever, unusual tiredness, and dark colored urine;
- pain or burning when you urinate;
- swelling, weight gain, urinating less than usual or not at all; or
- nausea, upper stomach pain, itching, loss of appetite, dark urine,...
Read All Potential Side Effects and See Pictures of Lescol »
What are the precautions when taking fluvastatin sodium (Lescol)?
Before taking fluvastatin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, alcohol use.
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
Limit alcoholic beverages. Daily use of alcohol may increase your risk for liver problems, especially when combined with fluvastatin. Ask your doctor or pharmacist for more information.
Older adults may be...
Read All Potential Precautions of Lescol »
Last reviewed on RxList: 3/12/2012
This monograph has been modified to include the generic and brand name in many instances.