Maxaquin (lomefloxacin HCl) is a synthetic broad-spectrum
antimicrobial agent for oral administration. Lomefloxacin HCl, a difluoroquinolone,
is the monohydrochloride salt of (±)-1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic
acid. Its empirical formula is C17H19F2N3O3•HCl,
and its structural formula is:
Lomefloxacin HCl is a white to pale yellow powder with a
molecular weight of 387.8. It is slightly soluble in water and practically insoluble
in alcohol. Lomefloxacin HCl is stable to heat and moisture but is sensitive to
light in dilute aqueous solution. Maxaquin is available as a film-coated tablet
formulation containing 400 mg of lomefloxacin base, present as the
hydrochloride salt. The base content of the hydrochloride salt is 90.6%. The
inactive ingredients are carboxymethylcellulose calcium, hydroxypropyl cellulose,
hypromellose, lactose, magnesium stearate, polyethylene glycol, polyoxyl 40
stearate, and titanium dioxide.
Last reviewed on RxList: 6/11/2012
This monograph has been modified to include the generic and brand name in many instances.