Leuprolide acetate is a synthetic nonapeptide analog of naturally occurring
gonadotropin-releasing hormone (GnRH or LH-RH). The analog possesses greater
potency than the natural hormone. The chemical name is 5oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide
acetate (salt) with the following structural formula:
LUPRON DEPOT-PED is available in a prefilled dual-chamber syringe containing
sterile lyophilized microspheres which, when mixed with diluent, become a suspension
intended as a single intramuscular injection.
The front chamber of LUPRON DEPOT-PED 7.5 mg, 11.25 mg, and 15 mg prefilled
dual-chamber syringe contains leuprolide acetate (7.5/11.25/15 mg), purified
gelatin (1.3/1.95/2.6 mg), DL-lactic and glycolic acids copolymer (66.2/99.3/132.4
mg), and D-mannitol (13.2/19.8/26.4 mg). The second chamber of diluent contains
carboxymethylcellulose sodium (5 mg), D-mannitol (50 mg), polysorbate 80 (1
mg), water for injection, USP, and glacial acetic acid, USP to control pH.
What are the possible side effects of leuprolide (Eligard, Lupron, Lupron Depot, Lupron Depot-Gyn, Lupron Depot-Ped)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
- bone pain, loss of movement in any part of your body;
- swelling, rapid weight gain;
- pain, burning, stinging, bruising, or redness where the medication was injected;
- feeling like you might pass out;
- painful or difficult urination;
- urinating more...
Read All Potential Side Effects and See Pictures of Lupron Depot Pediatric »
Last reviewed on RxList: 8/3/2012
This monograph has been modified to include the generic and brand name in many instances.