M-R-VAX® II (measles and rubella virus vaccine live) (Measles and Rubella Virus Vaccine Live), is a live virus vaccine for immunization against measles (rubeola) and rubella (German measles).
M-R-VAX (measles and rubella virus vaccine live) II is a sterile lyophilized preparation of (1) ATTENUVAX* (Measles Virus Vaccine Live), a more attenuated line of measles virus, derived from Enders' attenuated Edmonston strain and grown in cell cultures of chick embryo; and (2) MERUVAX* II (Rubella Virus Vaccine Live), the Wistar RA 27/3 strain of live attenuated rubella virus grown in human diploid cell (WI-38) culture. The vaccine viruses are the same as those used in the manufacture of ATTENUVAX (Measles Virus Vaccine Live) and MERUVAX II (Rubella Virus Vaccine Live). The two viruses are mixed before being lyophilized. The product contains no preservative.
The reconstituted vaccine is for subcutaneous administration. When reconstituted as directed, the dose for injection is 0.5 mL and contains not less than the equivalent of 1,000 TCID 50 (tissue culture infectious doses) of the U.S. Reference Measles Virus; and 1,000 TCID 50 of the U.S. Reference Rubella Virus. Each dose contains approximately 25 mcg of neomycin. The product contains no preservative. Sorbitol and hydrolized gelatin are added as stabilizers.
Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.