Korlym (mifepristone) is a cortisol receptor blocker for
oral administration. The chemical name of mifepristone is
9-dien-3-one. The chemical formula is C29H35NO2; the molecular weight is
429.60; and the structural formula is:
Mifepristone demonstrates a pH-related solubility profile.
The greatest solubility is achieved in acidic media (~ 25 mg/mL at pH 1.5) and
solubility declines rapidly as the pH is increased. At pH values above 2.5 the
solubility of mifepristone is less than 1 mg/mL.
Each Korlym tablet for oral use contains 300 mg of
mifepristone. The inactive ingredients of Korlym tablets are silicified
microcrystalline cellulose, sodium starch glycolate, hydroxypropylcellulose,
sodium lauryl sulfate, magnesium stearate, hypromellose, titanium dioxide,
triacetin, D&C yellow 10 aluminum lake, polysorbate 80, and FD&C yellow
6 aluminum lake.
Last reviewed on RxList: 2/23/2012
This monograph has been modified to include the generic and brand name in many instances.