Plasma-Lyte® M and 5% Dextrose Injection (Multiple Electrolytes and Dextrose
Injection, Type 2, USP) is a sterile, nonpyrogenic solution for fluid and electrolyte
replenishment and caloric supply in a single dose container for intravenous
administration. Each 100 mL contains 5 g Dextrose Hydrous, USP*, 161 mg Sodium
Acetate Trihydrate, USP (C2H3NaO2•3H2O);
138 mg Sodium Lactate (C3H5NaO3), 119 mg Potassium
Chloride, USP (KCl), 94 mg Sodium Chloride, USP (NaCl), 37 mg Calcium Chloride,
USP (CaCl2•2H2O), and 30 mg Magnesium Chloride, USP (MgCl2•6H2O).
It contains no antimicrobial agents. The pH is 5.0 (4.0 to 6.5).
The pH is adjusted with hydrochloric acid.
Plasma-Lyte® M and 5% Dextrose Injection (Multiple Electrolytes and Dextrose Injection, Type 2, USP) administered intravenously has value as a source of water, electrolytes, and calories. One liter has an ionic concentration of 40 mEq sodium, 16 mEq potassium, 5 mEq calcium, 3 mEq magnesium, 40 mEq chloride, 12 mEq acetate, and 12 mEq lactate. The osmolarity is 377 mOsmol/L (calc). Normal physiologic osmolarity range is approximately 280 to 310 mOsmol/L. Administration of substantially hypertonic solutions ( ≥ 600 mOsmol/L) may cause vein damage. The caloric content is 180 kcal/L.
The Viaflex® plastic container is fabricated from a specially formulated polyvinyl chloride (PL 146® Plastic). The amount of water that can permeate from inside the container into the overwrap is insufficient to affect the solution significantly. Solutions in contact with the plastic container may leach out certain chemical components from the plastic in very small amounts; however, biological testing was supportive of the safety of the plastic container materials.
Last reviewed on RxList: 5/20/2009
This monograph has been modified to include the generic and brand name in many instances.