Nafcillin Injection, USP is a sterile injectable product containing nafcillin
which is added as Nafcillin Sodium, USP, a semisynthetic penicillin derived
from the penicillin nucleus, 6aminopenicillanic acid. The chemical name of nafcillin
sodium is Monosodium (2S,5R,6R)-6-(2ethoxy-1-naphthamido)-3,3-dimethyl-7-oxo-4-thia-1-
azabicyclo[3.2.0]heptane-2-carboxylate monohydrate. It is resistant to inactivation
by the enzyme penicillinase (beta-lactamase). The molecular formula of Nafcillin
Sodium, USP is C21H21N2NaO5S•H2O.
The molecular weight is 454.48. The structural formula of nafcillin sodium is
Nafcillin Injection, USP is a frozen, iso-osmotic, sterile, nonpyrogenic premixed
50 mL or 100 mL solution containing 1 g or 2 g of nafcillin, respectively, added
as Nafcillin Sodium, USP. Dextrose, USP has been added to the above dosages
to adjust osmolality (approximately 1.8 g and 3.6 g as dextrose hydrous to the
1 g and 2 g dosages, respectively). Sodium Citrate Hydrous, USP has been added
as a buffer (approximately 90 mg and 180 mg to the 1 g and 2 g dosages, respectively).
The pH has been adjusted with hydrochloric acid and may have been adjusted with
sodium hydroxide. The pH is 6.5 (6.0 to 8.5). The solution is intended for intravenous
use after thawing to room temperature.
This GALAXY container is fabricated from a specially designed multilayer plastic
(PL 2040). Solutions are in contact with the polyethylene layer of this container
and can leach out certain chemical components of the plastic in very small amounts
within the expiration period. The suitability of the plastic has been confirmed
in tests in animals according to the USP biological tests for plastic containers,
as well as by tissue culture toxicity studies.
What are the possible side effects of nafcillin (Nallpen, Unipen)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives, itching; fever, stomach pain, muscle or joint pain; difficulty breathing; swelling of your face, lips, tongue, or throat. A delayed allergic reaction to nafcillin can occur as few as 2 days to as many as 4 weeks after you use the medication.
Call your doctor at once if you have any of these serious side effects:
- diarrhea that is watery or bloody;
- fever, chills, body aches, flu symptoms, sores in your mouth and throat;
- skin rash, bruising, severe tingling,...
Read All Potential Side Effects and See Pictures of Nafcillin Injection »
Last reviewed on RxList: 11/18/2011
This monograph has been modified to include the generic and brand name in many instances.