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CORTISPORIN® Ophthalmic Ointment
(neomycin and polymyxin B sulfates, bacitracin zinc, and hydrocortisone) Ophthalmic Ointment, USP

DRUG DESCRIPTION

CORTISPORIN® Ophthalmic Ointment (neomycin and polymyxin b sulfates, bacitracin zinc, and hydrocortisone ophthalmic ) (neomycin and polymyxin B sulfates, bacitracin zinc, and hydrocortisone ophthalmic ointment) is a sterile antimicrobial and anti- inflammatory ointment for ophthalmic use. Each gram contains: neomycin sulfate equivalent to 3.5 mg neomycin base, polymyxin B sulfate equivalent to 10,000 polymyxin B units, .bacitracin zinc equivalent to 400 bacitracin units, hydrocortisone 10 mg (1 %), and white petrolatum, q.s.

Neomycin sulfate is the sulfate salt of neomycin B and C, which are produced by the growth of Streptomyces fradiae Waksman (Fam. Streptomycetaceae ). It has a potency equivalent of not less than 600 µg of neomycin standard per mg, calculated on an anhydrous basis. The structural formulae are:

Neomycin sulfate structural formula illustration

Polymyxin B sulfate is the sulfate salt of polymyxin B1 and B2, which are produced by the growth of Bacillus polymyxa (Prazmowski) Migula (Fam. Bacillaceae). It has a potency of not less than 6,000 polymyxin B units per mg, calculated on an anhydrous basis. The structural formulae are:

Polymyxin B sulfate structural formula illustration

Bacitracin zinc is the zinc salt of bacitracin, a mixture of related cyclic polypeptides (mainly bacitracin A) produced by the growth of an organism of the licheniformis group of Bacillus subtilis var Tracy. It has a potency of not less than 40 bacitracin units per mg. The structural formula is:

Bacitracin zinc structural formula illustration

Hydrocortisone, 11β, 17, 21-trihydroxypregn-4-ene-3, 20-dione, is an anti-inflammatory hormone. Its structural formula is:

Hydrocortisone structural formula illustration

Last reviewed on RxList: 4/30/2008
This monograph has been modified to include the generic and brand name in many instances.