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NUBAIN®
(nalbuphine hydrochloride)

DRUG DESCRIPTION

NUBAIN (nalbuphine hydrochloride) is a synthetic opioid agonist-antagonist analgesic of the phenanthrene series. It is chemically related to both the widely used opioid antagonist, naloxone, and the potent opioid analgesic, oxymorphone. Chemically nalbuphine hydrochloride is 17-(cyclobutylmethyl)-4,5α-epoxymorphinan-3,6α,14-triol hydrochloride. Nalbuphine hydrochloride molecular weight is 393.91 and is soluble in H2O (35.5 mg/mL @ 25?C) and ethanol (0.8%); insoluble in CHCl3 and ether. Nalbuphine hydrochloride has pKa values of 8.71 and 9.96. The molecular formula is C21H27NO4·HCl. The structural formula is:

NUBAIN (nalbuphine hydrochloride) structural formula illustration

NUBAIN (nalbuphine hydrochloride) is a sterile solution suitable for subcutaneous, intramuscular, or intravenous injection. NUBAIN (nalbuphine hydrochloride) is available in two concentrations, 10 mg and 20 mg of nalbuphine hydrochloride per mL. Both strengths in 10 mL vials contain 0.94% sodium citrate hydrous, 1.26% citric acid anhydrous, and 0.2% of a 9:1 mixture of methylparaben and propylparaben as preservatives; pH is adjusted, if necessary, to 3.5 to 3.7 with hydrochloric acid. The 10 mg/mL strength contains 0.2% sodium chloride.

NUBAIN (nalbuphine hydrochloride) is also available in ampuls in a sterile, paraben-free formulation in two concentrations, 10 mg and 20 mg of nalbuphine hydrochloride per mL. One mL of each strength contains 0.94% sodium citrate hydrous, and 1.26% citric acid anhydrous; pH is adjusted, if necessary, to 3.5 to 3.7 with hydrochloric acid. The 10 mg/mL strength contains 0.2% sodium chloride.

What are the possible side effects of nalbuphine (Nubain)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if you have any of these serious side effects:

  • weak or shallow breathing;
  • fast or slow heart rate;
  • cold, clammy skin;
  • confusion, hallucinations, unusual thoughts or behavior;
  • severe weakness or dizziness; or
  • feeling like you might pass out.

Less serious side effects are more likely to occur, such as:

  • warmth, tingling, or...

Read All Potential Side Effects and See Pictures of Nubain »

Last reviewed on RxList: 1/4/2008
This monograph has been modified to include the generic and brand name in many instances.