NUROMAX (doxacurium chloride) is a long-acting, nondepolarizing skeletal muscle
relaxant for intravenous administration. Doxacurium chloride is [1α,2β(1'S*,2'R*)]-2,2'
methyl-1-[(3,4,5trimethoxyphenyl)methyl]isoquinolinium] dichloride (meso form).
The molecular formula is C56H78CI2N2O16
and the molecular weight is 1106.14. The compound does not partition into the
1octanol phase of a distilled water/ 1-octanol system, i.e., the n-octanol:water
partition coefficient is 0.
Doxacurium chloride is a mixture of three trans, trans stereoisomers, a dl
pair [(1R,1'R ,2S,2'S ) and (1S,1'S ,2R,2'R )] and a meso form (1R,1'S,2S,2'R).
The meso form is illustrated below:
NUROMAX (doxacurium chloride) Injection is a sterile, nonpyrogenic aqueous solution (pH 3.9 to 5.0)
containing doxacurium chloride equivalent to 1 mg/mL doxacurium in Water for
Injection. Hydrochloric acid may have been added to adjust pH. NUROMAX (doxacurium chloride) Injection
contains 0.9% w/v benzyl alcohol.
Last reviewed on RxList: 1/4/2011
This monograph has been modified to include the generic and brand name in many instances.