mebutate) gel, 0.015% or 0.05% is a clear colorless gel for topical
administration, which contains the active substance ingenol mebutate, an
inducer of cell death.
The chemical name of ingenol
mebutate is: 2-Butenoic acid, 2-methyl-, (1aR,2S,5R,5aS,6S,8aS,9R,10aR)-1a,2,5,5a,6,9,10,10a-octahydro5,5a-dihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-11-oxo-1H-2,8a-methanocyclopenta
[a]cyclopropa[e]cyclodecen-6-yl ester, (2Z) - or (1aR,2S,5R,5aS,6S,8aS,9R,10aR)-5,5a-dihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-11oxo-1a,2,5,5a,6,9,10,10a-octahydro-1H
2,8a-methanocyclopenta[a]cyclopropa[e]cyclodecen-6yl (2Z) 2 methylbut-2-enoate.
The molecular formula is C25H34O6
and molecular weight is 430.5. Ingenol mebutate is represented by the following
Ingenol mebutate is a white to
pale yellow crystalline powder.
Picato® gel, 0.015% and
0.05% contains 150 mcg and 500 mcg of ingenol mebutate, respectively in each
gram of gel consisting of isopropyl alcohol, hydroxyethyl cellulose, citric
acid monohydrate, sodium citrate, benzyl alcohol and purified water.
Picato® gel is clear
colorless gel and supplied in unit dose laminate tubes, for single use,
containing a nominal fill weight of 0.47 g, with a deliverable weight of 0.25
g. The tubes should be discarded after single use.
Last reviewed on RxList: 2/6/2012
This monograph has been modified to include the generic and brand name in many instances.