Mozobil (plerixafor injection) is a sterile, preservative-free, clear, colorless
to pale yellow, isotonic solution for subcutaneous injection. Each mL of the
sterile solution contains 20 mg of plerixafor. Each single-use vial is filled
to deliver 1.2 mL of the sterile solution that contains 24 mg of plerixafor
and 5.9 mg of sodium chloride in Water for Injection adjusted to a pH of 6.0
to 7.5 with hydrochloric acid and with sodium hydroxide, if required.
Plerixafor is a hematopoietic stem cell mobilizer with a chemical name 1, l'-[l,4-phenylenebis
(methylene)]-bis-l,4,8,11- tetraazacyclotetradecane. It has the molecular formula
C28H54N8. The molecular weight of plerixafor
is 502.79 g/mol. The structural formula is provided in Figure 1.
Figure 1: Structural Formula
Plerixafor is a white to off-white crystalline solid. It is hygroscopic. Plerixafor
has a typical melting point of 131.5 °C. The partition coefficient of plerixafor
between 1 -octanol and pH 7 aqueous buffer is < 0.1.
What are the possible side effects of plerixafor (Mozobil)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Tell your caregivers at once if you have a serious side effect such as:
- easy bruising or bleeding, unusual weakness;
- feeling like you might pass out; or
- pain in your upper stomach, spreading to your shoulder or back.
Less serious side effects may include:
- nausea, vomiting;
- diarrhea, constipation;
- dry mouth, numbness in or around your mouth;
Read All Potential Side Effects and See Pictures of Mozobil »
Last reviewed on RxList: 7/13/2010
This monograph has been modified to include the generic and brand name in many instances.