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QNASL™
(beclomethasone dipropionate)

DRUG DESCRIPTION

Beclomethasone dipropionate USP, the active component of QNASL Nasal Aerosol, is an anti-inflammatory steroid having the chemical name 9-chloro-11β,17,21-trihydroxy-16βmethylpregna-1,4-diene-3,20-dione 17, 21-dipropionate and the following chemical structure:

QNASL™ (beclomethasone dipropionate) Structural Formula Illustration

Beclomethasone dipropionate, a di-ester of beclomethasone (a synthetic corticosteroid chemically related to dexamethasone), is a white to almost white, odorless powder with a molecular formula of C28H37ClO7 and a molecular weight of 521.1. It is practically insoluble in water, very soluble in chloroform, and soluble in acetone and in dehydrated alcohol.

QNASL Nasal Aerosol is a pressurized, non-aqueous solution in a metered-dose aerosol device intended ONLY for intranasal use. It contains a solution of beclomethasone dipropionate in propellant HFA-134a (1,1,1,2-tetrafluoroethane) and dehydrated ethanol. Each actuation delivers 100 mcg of beclomethasone dipropionate in 59 mg of solution from the valve and delivers 80 mcg of beclomethasone dipropionate from the nasal actuator. Each canister contains 8.7 g of drug and excipients and provides 120 actuations after priming.

Last reviewed on RxList: 8/29/2012
This monograph has been modified to include the generic and brand name in many instances.