Beclomethasone dipropionate USP, the active component of
QNASL Nasal Aerosol, is an anti-inflammatory steroid having the chemical name
17, 21-dipropionate and the following chemical structure:
Beclomethasone dipropionate, a
di-ester of beclomethasone (a synthetic corticosteroid chemically related to
dexamethasone), is a white to almost white, odorless powder with a molecular
formula of C28H37ClO7 and a molecular weight
of 521.1. It is practically insoluble in water, very soluble in chloroform, and
soluble in acetone and in dehydrated alcohol.
QNASL Nasal Aerosol is a
pressurized, non-aqueous solution in a metered-dose aerosol device intended
ONLY for intranasal use. It contains a solution of beclomethasone dipropionate
in propellant HFA-134a (1,1,1,2-tetrafluoroethane) and dehydrated ethanol. Each
actuation delivers 100 mcg of beclomethasone dipropionate in 59 mg of solution
from the valve and delivers 80 mcg of beclomethasone dipropionate from the
nasal actuator. Each canister contains 8.7 g of drug and excipients and
provides 120 actuations after priming.
Last reviewed on RxList: 8/29/2012
This monograph has been modified to include the generic and brand name in many instances.