QUILLIVANT XR is a powder that, after reconstitution with
water, forms an extended-release oral suspension formulation of methylphenidate
intended for once daily oral administration. QUILLIVANT XR contains
approximately 20% immediate-release and 80% extended-release methylphenidate.
After reconstitution, QUILLIVANT XR is available in a 25 mg per 5 mL (5 mg per
mL) extended-release oral suspension.
Methylphenidate HCl is a central nervous system (CNS)
stimulant. The chemical name is methyl α-phenyl-2-piperidineacetate hydrochloride,
and its structural formula is shown in Figure 1.
Figure 1: Methylphenidate HCl structure
C14H19NO2 HCl Mol. Wt.
Methylphenidate HCl is a white, odorless crystalline powder.
Its solutions are acid to litmus. It is freely soluble in water and in methanol,
soluble in alcohol, and slightly soluble in chloroform and in acetone.
QUILLIVANT XR also contains the following inactive
ingredients: sodium polystyrene sulfonate, povidone, triacetin, polyvinol, sucrose,
anhydrous trisodium citrate, anhydrous citric acid, sodium benzoate, sucralose,
poloxamer 188, corn starch, xanthan gum, talc, banana flavor, and silicon
Last reviewed on RxList: 10/15/2012
This monograph has been modified to include the generic and brand name in many instances.