Table 3. Description
| Dosage Form:
|| White, film-coated tablet
|Route of Administration:
|Pharmacologic Class of Drug:
| Chemical Name:
|| (±) 4-amino-5-hexenoic acid
SABRIL (vigabatrin) is available as a white, film-coated tablet for oral administration.
Each tablet contains 500 mg vigabatrin. Tablets also contain as inactive ingredients:
hydroxypropyl methylcellulose, magnesium stearate, microcrystalline cellulose,
polyethylene glycols, povidone, sodium starch glycolate, and titanium dioxide.
Vigabatrin is an oral antiepileptic drug with the chemical name (±) 4-amino-5-hexenoic
acid. It is a racemate consisting of two enantiomers. The molecular formula
is C6H11NO2 and the molecular weight is 129.16.
Vigabatrin is a white to off-white powder which is freely soluble in water,
slightly soluble in methyl alcohol, very slightly soluble in ethyl alcohol and
chloroform, and insoluble in toluene and hexane. The pH of a 1% aqueous solution
is about 6.9. The n-octanol/water partition coefficient of vigabatrin is about
0.011 (log P=-1.96) at physiologic pH. Vigabatrin melts with decomposition
in a 3-degree range within the temperature interval of 171°C to 176°C.
The dissociation constants (pKa) of vigabatrin are 4 and 9.7 at room
What are the possible side effects of vigabatrin (Sabril)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
- any change in your vision, no matter how mild;
- back and forth eye movements you cannot control;
- pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating;
- worsening seizures; or
- confusion, mood or behavior changes, depression, thoughts about suicide or hurting...
Read All Potential Side Effects and See Pictures of Sabril »
Last reviewed on RxList: 3/7/2011
This monograph has been modified to include the generic and brand name in many instances.