SEMPREX-D Capsules (acrivastine and pseudoephedrine
hydrochloride) are a fixed combination product formulated for oral administration.
Acrivastine is an antihistamine and pseudoephedrine is a decongestant. Each
capsule contains 8 mg acrivastine and 60 mg pseudoephedrine hydrochloride and
the inactive ingredients: lactose, magnesium stearate and sodium starch
glycolate. The green and white capsule shell consists of gelatin, D&C
Yellow No. 10, FD&C Green No. 3, and titanium dioxide. The yellow band
around the capsule consists of gelatin and D&C Yellow No. 10. The capsules
may contain one or more parabens and are printed with edible black and white
The chemical name of acrivastine is
acid; the molecular formula is C22H24N2O2. As an analog of triprolidine
hydrochloride, acrivastine is classified as an alkylamine antihistamine. Acrivastine
is an odorless, white to pale cream crystalline powder that is soluble in
chloroform and alcohol and slightly soluble in water.
The chemical name of pseudoephedrine hydrochloride is
[S-(R*,R*)]-α-[1-(methylamino)ethyl]benzenemethanol hydrochloride; the molecular
formula is C10H15NO•HCl. Pseudoephedrine is one of the
naturally occurring dextrorotatory diastereoisomers of ephedrine and is
classified as an indirect sympathomimetic amine. Pseudoephedrine hydrochloride
occurs as odorless, fine white to off-white crystals or powder; the drug is
soluble in water, alcohol and chloroform.
Structural formulae for the active ingredients of SEMPREX-D (acrivastine and pseudoephedrine)
Capsules are as follows:
(a) Acrivastine (Molecular Weight = 348.44)
(b) Pseudo ephedrine hydrochloride (Molecular Weight =
What are the possible side effects of acrivastine and pseudoephedrine (Semprex-D)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using this medicine and call your doctor at once if you have a serious side effect such as:
- fast, pounding, or uneven heartbeat;
- severe dizziness or anxiety;
- confusion, hallucinations, unusual thoughts or behavior;
- urinating less than usual or not at all;
- easy bruising or bleeding, unusual weakness, fever, chills, body aches, flu symptoms;...
Read All Potential Side Effects and See Pictures of Semprex D »
Last reviewed on RxList: 5/20/2009
This monograph has been modified to include the generic and brand name in many instances.