NUCYNTA® ER (tapentadol) is a mu-opioid receptor agonist,
supplied in extended-release film-coated tablets for oral administration,
containing 58.24, 116.48, 174.72, 232.96, and 291.20 mg of tapentadol
hydrochloride in each tablet strength, corresponding to 50, 100, 150, 200, and 250
mg of tapentadol free-base, respectively. The chemical name is 3-[(1R,2R)-3-(dimethylamino)-1-ethyl-2-
methylpropyl]phenol monohydrochloride. The structural formula is:
The molecular weight of tapentadol HCl is 257.80, and the
molecular formula is C14H23NO•HCl. The n-octanol: water
partition coefficient log P value is 2.89. The pKa values are 9.36 and 10.45.
In addition to the active ingredient tapentadol HCl, tablets also contain the
following inactive ingredients: alpha-tocopherol (vitamin E), hypromellose,
polyethylene glycol, and polyethylene oxide. The film coating is comprised of
polyvinyl alcohol, polyethylene glycol, talc, titanium dioxide, and the
colorant FD&C Blue #2 aluminum lake is used for 100, 150, 200, and 250 mg
strengths; and additionally, yellow iron oxide is used in 150 mg tablets. Printing
inks contain shellac glaze and propylene glycol for all strengths, and black iron
oxide (50, 100, 150 and 200 mg tablets) or titanium dioxide (250 mg tablets).
What are the possible side effects of tapentadol (Nucynta, Nucynta ER)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
- weak or shallow breathing, weak pulse, slow heartbeat;
- seizure (convulsions);
- severe drowsiness or dizziness;
- confusion, problems with speech or balance; or
- agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination,...
Read All Potential Side Effects and See Pictures of Nucynta ER »
Last reviewed on RxList: 10/5/2012
This monograph has been modified to include the generic and brand name in many instances.