Teflaro is a sterile, semi-synthetic, broad-spectrum, prodrug antibacterial of
cephalosporin class of beta-lactams (p-lactams). Chemically, the prodrug, ceftaroline
fosamil monoacetate monohydrate is
monoacetate monohydrate. Its molecular weight is 762.75. The empirical formula
Figure 1: Chemical structure of ceftaroline fosamil
Teflaro vials contain either 600 mg or 400 mg of anhydrous ceftaroline fosamil. The
powder for injection is formulated from ceftaroline fosamil monoacetate
monohydrate, a pale yellowish-white to light yellow sterile powder. All
references to ceftaroline activity are expressed in terms of the prodrug,
ceftaroline fosamil. The powder is constituted for IV injection [see DOSAGE
Each vial of Teflaro contains ceftaroline fosamil and L-arginine, which results in a
constituted solution at pH 4.8 to 6.5.
What are the possible side effects of ceftaroline (Teflaro)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:
- diarrhea that is watery or bloody;
- chest pain;
- fever, chills, body aches, flu symptoms;
- unusual bleeding;
- seizure (convulsions);
- pale or yellowed skin, dark colored urine, fever, confusion or weakness;
- jaundice (yellowing of the skin or eyes);
- fever, sore throat, and headache with a...
Read All Potential Side Effects and See Pictures of Teflaro »
Last reviewed on RxList: 11/5/2012
This monograph has been modified to include the generic and brand name in many instances.