TIMENTIN is a sterile injectable antibacterial combination consisting of the
semisynthetic antibiotic ticarcillin disodium and the β-lactamase inhibitor
clavulanate potassium (the potassium salt of clavulanic acid) for intravenous
administration. Ticarcillin is derived from the basic penicillin nucleus, 6-amino-penicillanic
Chemically, ticarcillin disodium is N-(2-Carboxy-3,3-dimethyl-7-oxo-4-thia-1azabicyclo[3.2.0]hept-6-yl)-3-thiophenemalonamic
acid disodium salt and may be represented as:
Clavulanic acid is produced by the fermentation of Streptomyces clavuligerus.
It is a β-lactam structurally related to the penicillins and possesses
the ability to inactivate a wide variety of β-lactamases by blocking the
active sites of these enzymes. Clavulanic acid is particularly active against
the clinically important plasmid-mediated β-lactamases frequently responsible
for transferred drug resistance to penicillins and cephalosporins.
Chemically, clavulanate potassium is potassium (Z)-(2R,5R)-3-(2-hydroxyethylidene)-7oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylate
and may be represented structurally as:
TIMENTIN is supplied as a white to pale yellow powder for reconstitution. TIMENTIN
is very soluble in water, its solubility being greater than 600 mg/mL. The reconstituted
solution is clear, colorless or pale yellow, having a pH of 5.5 to 7.5.
For the 3.1-gram dosage of TIMENTIN, the theoretical sodium content is 4.51
mEq (103.6 mg) per gram of TIMENTIN. The theoretical potassium content is 0.15
mEq (6 mg) per gram of TIMENTIN.
What are the possible side effects of ticarcillin and clavulanate potassium (Timentin)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:
- diarrhea that is watery or bloody;
- blood in your urine, feeling an urgent need to urinate, painful or difficult urination;
- easy bruising or bleeding, unusual weakness;
- dry mouth, increased thirst, confusion, increased urination, muscle pain or weakness, fast heart rate, feeling...
Read All Potential Side Effects and See Pictures of Timentin »
Last reviewed on RxList: 6/28/2011
This monograph has been modified to include the generic and brand name in many instances.